Comparative Study of Blue Light with Ultraviolet (UVC) Radiation on Betacoronavirus 1

The ongoing coronavirus pandemic requires more effective disinfection methods. Disinfection using ultraviolet light (UV), especially longer UVC wavelengths, such as 254 and 270/280 nm, has been proven to have virucidal properties, but its adverse effects on human skin eyes limit use enclosed, unoccupied spaces. Several studies shown the effectiveness of blue (405 nm) against bacteria fungi, property at 405 nm not much investigated. Based previous studies, visible mediates inactivation by absorbing porphyrins reacting with oxygen produce reactive species (ROS). This causes oxidative damage biomolecules, proteins, lipids, nucleic acids, essential constituents any virus. potential speculated because virus lacks porphyrins. study demonstrated porphyrin-independent viral conducted a comparative analysis other wavelengths. betacoronavirus 1 (strain OC43) was exposed 405, 270/280, 254, 222 efficacy determined median tissue culture infectious dose, i.e., TCID50. results support technology providing quantitative effect that can serve basic groundwork for future technologies. In future, usage be widened hospitals, public places, aircraft cabins, and/or laboratories purposes.